Immobilization of biomolecules via ruthenium-catalyzed functionalization of the surface of silica with a vinylsilane

G Hreczycho, MK Chmielewski, H Maciejewski…

文献索引：Hreczycho, Grzegorz; Chmielewski, Marcin K.; MacIejewski, Hieronim; Ratajczak, Tomasz; Marciniec, Bogdan Tetrahedron Letters, 2013 , vol. 54, # 28 p. 3605 - 3608

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被引用次数: 3

摘要

A new ruthenium complex catalyzed procedure for the efficient O-silylation of an SiO–H group on the silica surface of glass beads with controlled pores (CPG) using 1- trimethylsiloxy-3-dimethylvinylsilylpropane leading to Si–O–Si bond formation with the evolution of ethylene is described. The formed linker contains alkyl hydroxyl groups which can be reacted with a nucleoside phosphoramidite unit. The CPG support containing alkyl ...