Preparation of 5'-O-phosphonylmethyl analogues of nucleoside-5'-phosphates, 5'-diphosphates and 5'-triphosphates

A Holý, I Rosenberg

文献索引：Holy, Antonin; Rosenberg, Ivan Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 12 p. 3447 - 3463

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被引用次数: 100

摘要

Abstract Reaction of a trialkyl phosphite (VI) or sodium salt of dialkyl phosphite (V) with bromomethyl acetate afforded dialkyl acetoxymethanephosphonates VII which were alcoholyzed to dialkyl hydroxymethanephosphonates VIII. Tosylation of the compounds VIII gave dialkyl p-toluenesulfonyloxymethanephosphonates IX which on reaction with 2', 3'-O- isopropylideneribonucleosides (I), 2', 3'-O-ethoxymethyleneribonucleosides (XI) or 3'-O- ...