Tetrahedron

Halogenation of pyridinium-N-(2′-pyridyl) aminide: An easy synthesis of halo-2-aminopyridines

…, JL García-Navío, ML Izquierdo, J Alvarez-Builla

文献索引：Burgos; Delgado; Garcia-Navio; Izquierdo; Alvarez-Builla Tetrahedron, 1995 , vol. 51, # 31 p. 8649 - 8654

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被引用次数: 33

摘要

The regioselective halogenation of pyridinium-N-(2′-pyridyl) aminide 1 with N-chloro, bromo or iodosuccinimide under mild conditions is described. The method, combined with a reduction of the NN bond, allows an easy preparation of 5-halo and 3, 5-dihalo-2- aminopyridines 4.