Modular fluorescent-labeled siderophore analogues

R Nudelman, O Ardon, Y Hadar, Y Chen…

文献索引：Nudelman, Raphael; Ardon, Orly; Hadar, Yitzhak; Chen, Yona; Libman, Jacqueline; Shanzer, Abraham Journal of Medicinal Chemistry, 1998 , vol. 41, # 10 p. 1671 - 1678

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被引用次数: 72

摘要

Biomimetic analogues 1 of the microbial siderophore (iron carrier) ferrichrome were labeled via piperazine with various fluorescent markers at a site not interfering with iron binding or receptor recognition (compounds 10-12). These iron carriers were built from a tetrahedral carbon symmetrically extended with three strands, each containing an amino acid (G= glycyl, A= alanyl, L= leucyl and P= phenylalanyl) and terminated by a hydroxamic acid, ...