Chemistry letters

Synthesis of a novel pyrrolidine-based peptide nucleic acid that contains tertiary amines in the main chain and its internalization into cells

M Kitamatsu, T Kashiwagi, R Matsuzaki, M Sisido

文献索引：Kitamatsu, Mizuki; Kashiwagi, Tomoko; Matsuzaki, Rino; Sisido, Masahiko Chemistry Letters, 2006 , vol. 35, # 3 p. 300 - 301

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被引用次数: 10

摘要

A novel thymine monomer of pyrrolidine-based peptide nucleic acid that contains tertiary amines in the main chain (pyrrolidine-based amino peptide nucleic acid= PAPNA) was synthesized. A mixed oligomer of two PAPNA (T) units and seven units of pyrrolidine-based oxypeptide nucleic acid (POPNA), was synthesized by a solid-phase method. The mixed oligomer was internalized into CHO cells more readily than the previous version of ...