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Synthesis of new phosphonated tripod ligands as putative new therapeutic agents in the chelation treatment of metal intoxications

R Burgada, T Bailly, M Lecouvey…

文献索引:Burgada, Ramon; Bailly, Theodorine; Lecouvey, Marc; Larue, Valery; Leroux, Yves European Journal of Organic Chemistry, 2001 , # 2 p. 349 - 352

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被引用次数: 3

摘要

Abstract In a quest for new chelation therapy drugs for the treatment of intoxication by actinides, some new phosphonated chelating tripod ligands have been synthesized. They have been obtained by means of a coupling reaction between a diethylphosphonoalkanoic acid activated with N, N′-disuccinimidyl carbonate (DSC) and a series of polyamines, with subsequent deprotection of the phosphonate groups.