Synthesis and pharmacological evaluation of chlorinated N-alkyl-3-and-5-(2-hydroxyphenyl) pyrazoles as CB 1 cannabinoid ligands

…, N Jagerovic, LF Callado, JAS Cavaleiro…

文献索引：Silva, Vera L. M.; Silva, Artur M. S.; Pinto, Diana C. G. A.; Jagerovic, Nadine; Callado, Luis F.; Cavaleiro, Jose A. S.; Elguero, Jose Monatshefte fur Chemie, 2007 , vol. 138, # 8 p. 797 - 811

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被引用次数: 9

摘要

Summary. The syntheses of several new 3-and 5-(4-chloro-2-hydroxyphenyl)-5-and-3-(2, 4- dichlorophenyl)-1-alkylpyrazoles are reported. These syntheses started from simple chlorophenols, 2, 4-dichlorobenzaldehyde or ethyl 2, 4-dichlorobenzoate in order to prepare pyrazoles bearing three and four chloro substituents in certain positions. The affinity of these compounds towards the CB 1 type cannabinoids receptors was then evaluated in human ...