A Highly Efficient Synthesis of Rocaglaols by a Novel α??Arylation of Ketones

N Diedrichs, JP Ragot, K Thede

文献索引：Diedrichs, Nicole; Ragot, Jacques P.; Thede, Kai European Journal of Organic Chemistry, 2005 , # 9 p. 1731 - 1735

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被引用次数: 16

摘要

Abstract Rocaglaols are natural products exhibiting a range of biological activities. A new synthetic method for the α-arylation of ketones allows for the synthesis of previously inaccessible rocaglaol derivatives. The key sequence consists of a previously unreported Suzuki type reaction using brominated silyl enol ethers as substrates followed by deprotection of the arylated silyl enol ethers.(© Wiley-VCH Verlag GmbH & Co. KGaA, ...