Synthesis of methoxylated goniothalamin, aza-goniothalamin and γ-pyrones and their in vitro evaluation against human cancer cells

…, JC Pastre, V Caixeta, DB Vendramini-Costa…

文献索引：Barcelos, Rosimeire Coura; Pastre, Julio Cezar; Caixeta, Vanessa; Vendramini-Costa, Debora Barbosa; De Carvalho, Joao Ernesto; Pilli, Ronaldo Aloise Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 11 p. 3635 - 3651

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被引用次数: 22

摘要

The present work describes the preparation of three novel series of compounds based on the structure of goniothalamin, a natural styryl lactone which has been found to display cytotoxic and antiproliferative activities against a variety of cancer cell lines. A focused library of 29 novel goniothalamin analogues was prepared and evaluated against seven human cancer cell lines. While the γ-pyrones and the aza-goniothalamin analogues were ...