Tetrahedron

Highly enantioselective cyanosilylation of aldehydes catalyzed by a Lewis acid–Lewis base bifunctional catalyst

Y Hamashima, D Sawada, H Nogami, M Kanai…

文献索引：Hamashima, Yoshitaka; Sawada, Daisuke; Nogami, Hiroyuki; Kanai, Motomu; Shibasaki, Masakatsu Tetrahedron, 2001 , vol. 57, # 5 p. 805 - 814

全文：HTML全文

被引用次数: 138

摘要

A new bifunctional asymmetric catalyst containing a Lewis acid and a Lewis base (1) was developed and applied to the catalytic asymmetric cyanosilylation of aldehydes. The products were obtained generally with excellent enantiomeric excess. The experiments using the control catalyst (5) and the catalyst containing more electron-rich phosphine oxide (6) suggest that the catalyst 1 should promote the reaction via a dual activation of the ...