Design, synthesis, and antiviral evaluations of 1-(substituted benzyl)-2-substituted-5, 6-dichlorobenzimidazoles as nonnucleoside analogues of 2, 5, 6-trichloro-1-(β-D …

…, LS Kucera, JC Drach, LB Townsend

文献索引：Porcari, Anthony R.; Devivar, Rodrigo V.; Kucera, Louis S.; Drach, John C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 1998 , vol. 41, # 8 p. 1252 - 1262

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被引用次数: 250

摘要

We have recently reported that certain ribosylated polyhalogenated benzimidazoles are potent and selective inhibitors of HCMV replication at noncytotoxic concentrations. To extend the structure-activity relationship beyond these first-generation compounds, we alkylated 5, 6-dichloro-2-substituted-benzimidazoles with either a series of substituted benzyl halides or (2-bromoethyl) benzene to obtain five series of nonnucleoside ...