Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo [1, 2-b] pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor

S Huang, R Lin, Y Yu, Y Lu, PJ Connolly, G Chiu…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 5 p. 1243 - 1245

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被引用次数: 84

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Though all the three unsubstituted carbons (C-4, C-6, C-7) of the indazole ring could potentially be replaced with nitrogen, only the chemistry for pyrazolo[1,2-b]pyridine synthesis was successfully developed. ...