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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis and c-Src inhibitory activity of imidazo [1, 5-a] pyrazine derivatives as an agent for treatment of acute ischemic stroke

…, S Kobayashi, T Ozawa, N Kamada, Y Komatsu…

文献索引：Mukaiyama, Harunobu; Nishimura, Toshihiro; Kobayashi, Satoko; Ozawa, Tomonaga; Kamada, Noboru; Komatsu, Yoshimitsu; Kikuchi, Shinji; Oonota, Hideki; Kusama, Hiroshi Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 868 - 885

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被引用次数: 32

摘要

We synthesized and evaluated a series of C-5 substituted imidazo [1, 5-a] pyrazine derivatives to identify potent c-Src inhibitors as potential therapeutic agents for acute ischemic stroke. Among these compounds, compound 14c· HCl demonstrated remarkable central nervous system (CNS) penetration and significant neuroprotective efficacy in vivo in rat models.

7-[(4-methoxyphenyl)methyl]-5-phenylimidazo[1,5-a]pyrazin-8-one结构式

7-[(4-methoxyph...

~57%

5-phenyl-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-phenyl-7H-imi...

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1-(4-methoxybenzyl)-5-phenylpyrazin-2(1H)-one结构式

1-(4-methoxyben...

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5-phenyl-7H-imidazo[1,5-a]pyrazin-8-one结构式

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苯基丙醇水合物结构式

苯基丙醇水合物

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5-phenyl-7H-imidazo[1,5-a]pyrazin-8-one结构式

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5-苯基-1H-吡嗪-2-酮结构式

5-苯基-1H-吡嗪-2-酮

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5-phenyl-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-phenyl-7H-imi...

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7-(4-methoxybenzyl)-5-(4-methoxyphenyl)imidazo[1,5-a]pyrazin-8(7H)-one结构式

7-(4-methoxyben...

~64%

5-(4-methoxyphenyl)-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-(4-methoxyphe...

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1-(4-methoxybenzyl)-5-(4-methoxyphenyl)pyrazin-2(1H)-one结构式

1-(4-methoxyben...

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5-(4-methoxyphenyl)-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-(4-methoxyphe...

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5-(4-甲氧基苯基)-1H-吡嗪-2-酮结构式

5-(4-甲氧基苯基)-1H-...

~%

5-(4-methoxyphenyl)-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-(4-methoxyphe...

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2-(4-甲氧基苯基)-2-氧代乙醛结构式

2-(4-甲氧基苯基)-2-氧代乙醛

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5-(4-methoxyphenyl)-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-(4-methoxyphe...

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N-(2,6-dimethylphenyl)-5-(4-methoxyphenyl)imidazo[1,5-a]pyrazin-8-amine结构式

N-(2,6-dimethyl...

~88%

4-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

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5-(4-methoxyphenyl)-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-(4-methoxyphe...

~%

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1-(4-methoxybenzyl)-5-(4-methoxyphenyl)pyrazin-2(1H)-one结构式

1-(4-methoxyben...

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4-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

4-[8-(2,6-dimet...

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7-(4-methoxybenzyl)-5-(4-methoxyphenyl)imidazo[1,5-a]pyrazin-8(7H)-one结构式

7-(4-methoxyben...

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4-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

4-[8-(2,6-dimet...

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5-(4-甲氧基苯基)-1H-吡嗪-2-酮结构式

5-(4-甲氧基苯基)-1H-...

~%

4-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

4-[8-(2,6-dimet...

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2-(4-甲氧基苯基)-2-氧代乙醛结构式

2-(4-甲氧基苯基)-2-氧代乙醛

~%

4-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

4-[8-(2,6-dimet...

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N-(2,6-dimethylphenyl)-5-(3-methoxyphenyl)imidazo[1,5-a]pyrazin-8-amine结构式

N-(2,6-dimethyl...

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3-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

3-[8-(2,6-dimet...

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5-bromo-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-bromo-7H-imid...

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3-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

3-[8-(2,6-dimet...

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5-bromo-7-(4-methoxybenzyl)imidazo[1,5-a]pyrazin-8(7H)-one结构式

5-bromo-7-(4-me...

~%

3-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

3-[8-(2,6-dimet...

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5-bromo-N-(2,6-dimethylphenyl)imidazo[1,5-a]pyrazin-8-amine结构式

5-bromo-N-(2,6-...

~%

3-[8-(2,6-dimethylanilino)imidazo[1,5-a]pyrazin-5-yl]phenol结构式

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甘氨酰胺盐酸盐结构式

甘氨酰胺盐酸盐

2-(4-甲氧基苯基)-2-氧代乙醛结构式

2-(4-甲氧基苯基)-2-氧代乙醛

~62%

5-(4-甲氧基苯基)-1H-吡嗪-2-酮结构式

5-(4-甲氧基苯基)-1H-...

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5-bromo-7-(4-methoxybenzyl)imidazo[1,5-a]pyrazin-8(7H)-one结构式

5-bromo-7-(4-me...

~83%

5-bromo-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-bromo-7H-imid...

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5-bromo-7H-imidazo[1,5-a]pyrazin-8-one结构式

5-bromo-7H-imid...

~%

5-bromo-N-(2,6-dimethylphenyl)imidazo[1,5-a]pyrazin-8-amine结构式

5-bromo-N-(2,6-...

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5-bromo-7-(4-methoxybenzyl)imidazo[1,5-a]pyrazin-8(7H)-one结构式

5-bromo-7-(4-me...

~%

5-bromo-N-(2,6-dimethylphenyl)imidazo[1,5-a]pyrazin-8-amine结构式

5-bromo-N-(2,6-...

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3'-甲氧基苯乙酰溴[用于高效液相色谱标记]结构式

3'-甲氧基苯乙酰溴[用于高效...

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6-(3-methoxyphenyl)-7H-imidazo[1,5-a]pyrazin-8-one结构式

6-(3-methoxyphe...

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2-溴-4'-氟苯乙酮结构式

2-溴-4'-氟苯乙酮

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6-(4-fluorophenyl)-7H-imidazo[1,5-a]pyrazin-8-one结构式

6-(4-fluorophen...

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1-(4-methoxybenzyl)-5-phenylpyrazin-2(1H)-one结构式

1-(4-methoxyben...

4-toluene-sulfonylmethyl isocyanide结构式

4-toluene-sulfo...

~99%

7-[(4-methoxyphenyl)methyl]-5-phenylimidazo[1,5-a]pyrazin-8-one结构式

7-[(4-methoxyph...

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苯基丙醇水合物结构式

苯基丙醇水合物

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7-[(4-methoxyphenyl)methyl]-5-phenylimidazo[1,5-a]pyrazin-8-one结构式

7-[(4-methoxyph...

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5-苯基-1H-吡嗪-2-酮结构式

5-苯基-1H-吡嗪-2-酮

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7-[(4-methoxyphenyl)methyl]-5-phenylimidazo[1,5-a]pyrazin-8-one结构式

7-[(4-methoxyph...

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