Synthesis of new (.+-.)-3, 5-dihydroxypentyl nucleoside analogs from 1-amino-5-(benzyloxy) pentan-3-ol and their antiviral evaluation

M Legraverend, H Boumchita, A Zerial…

文献索引：Legraverend, Michel; Boumchita, Hassane; Zerial, Aurelio; Huel, Christiane; Lemaitre, Marc; Bisagni, Emile Journal of Medicinal Chemistry, 1990 ,  vol. 33,  # 9  p. 2476 - 2480

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被引用次数: 13

摘要

The synthesis and antiviral evaluation of a series of (*)-3, 5-dihydroxypentyl nucleoside analogues related to acyclic nucleoside antiviral agents are reported. All purine and pyrimidine nucleoside analogues described in this paper have been obtained from l-amino- 5-(benzyloxy) pentan-3-o1. A synthesis of this amine is reported from 1-(benzyloxy) but-3- ene after epoxidation and regiospecific diethylaluminum chloride catalyzed opening of the ...