Organic letters

Total Synthesis of Lysergic Acid

S Umezaki, S Yokoshima, T Fukuyama

文献索引：Umezaki, Satoshi; Yokoshima, Satoshi; Fukuyama, Tohru Organic Letters, 2013 ,  vol. 15,  # 16  p. 4230 - 4233

全文：HTML全文

被引用次数: 20

摘要

A total synthesis of lysergic acid was accomplished. Key features of our synthesis include stereoselective construction of the stereogenic centers at the allylic positions by using the Evans aldol reaction, and a sequential process with a ring-closing metathesis and an intramolecular Heck reaction to construct the C and D rings.