Tetrahedron

Stereoselective total synthesis of natural phytol via double bond reductions by baker's yeast

P Gramatica, P Manitto, D Monti, G Speranza

文献索引：Gramatica, Paola; Manitto, Paolo; Monti, Diego; Speranza, Giovanna Tetrahedron, 1987 ,  vol. 43,  # 19  p. 4481 - 4486

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被引用次数: 35

摘要

Natural (E)-(7R, 11R)-Phytol (1), a component of the chlorophyll molecule, vitamin K1 (2) and other natural compounds, was synthesized in enantiomerically and diastereomerically pure form by Li2CuCl4-induced coupling of two C10-units (8, 12). Both these units were prepared from geraniol (3) via enzymatic enantioselective hydrogenation of activated double bonds.