Tetrahedron: Asymmetry

Lipase-catalyzed kinetic resolution of β-borylated carboxylic esters

JS Reis, LH Andrade

文献索引：Reis, Joel S.; Andrade, Leandro H. Tetrahedron Asymmetry, 2012 ,  vol. 23,  # 17  p. 1294 - 1300

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被引用次数: 9

摘要

The kinetic resolution of chiral β-borylated carboxylic esters via lipase-catalyzed hydrolysis and transesterification reactions was studied. The enantioselective hydrolysis catalyzed by CAL-B furnished the β-borylated carboxylic acid with reasonable enantiomeric excess (62% ee), while both methyl and ethyl β-borylated carboxylic esters were recovered with excellent ee (> 99%). Meanwhile, the transesterification reaction of β-borylated carboxylic esters ...