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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Tetrahedron letters

Total synthesis of 20-hydroxy-and 20-carboxy-leukotrienes B 4

KC Nicolaou, YS Chung, PE Hernandez, IM Taffer…

文献索引：Nicolaou, K. C.; Chung, Y. S.; Hernandez, P. E.; Taffer, I. M.; Zipkin, R. E. Tetrahedron Letters, 1986 , vol. 27, # 17 p. 1881 - 1882

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被引用次数: 5

摘要

... Abstract. The total synthesis of 20-hydroxy- and 20-carboxy-leukotrienes B 4 (1 and 2) from key intermediates 13, 14 and 15 is described. References. 1; S Shak, IM Goldstein; J. Biol. ... For a previous synthesis of these metabolites see Tetrahedron Lett., 23 (1982), p. 4751. ... All new compounds in were characterized by spectroscopic (IR, MS, UV, NMR) and analytical and/or exact mass measurements. 7; KC Nicolaou, RE Zipkin, RE Dolle, BD Harris; J. Am. Chem. ...

(9R)-methyl 9-hydroxy-10-((tetrahydro-2H-pyran-2-yl)oxy)dec-6-ynoate结构式

(9R)-methyl 9-h...

~%

(5S,6Z,8E,10E,12R,14Z)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenedioate结构式

(5S,6Z,8E,10E,1...

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(R)-methyl 9-((tert-butyldiphenylsilyl)oxy)-10-oxodec-6-ynoate结构式

(R)-methyl 9-((...

~%

(5S,6Z,8E,10E,12R,14Z)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenedioate结构式

(5S,6Z,8E,10E,1...

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methyl (R)-9-((tert-butyldiphenylsilyl)oxy)-10-hydroxydec-6-ynoate结构式

methyl (R)-9-((...

~%

(5S,6Z,8E,10E,12R,14Z)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenedioate结构式

(5S,6Z,8E,10E,1...

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(9R)-methyl 9-((tert-butyldiphenylsilyl)oxy)-10-((tetrahydro-2H-pyran-2-yl)oxy)dec-6-ynoate结构式

(9R)-methyl 9-(...

~%

(5S,6Z,8E,10E,12R,14Z)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenedioate结构式

(5S,6Z,8E,10E,1...

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(5S,8E,10E,12R)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-8,10-dien-6,14-diynedioate结构式

(5S,8E,10E,12R)...

~%

(5S,6Z,8E,10E,12R,14Z)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenedioate结构式

(5S,6Z,8E,10E,1...

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1-(tert-butyldiphenylsilyloxy)hept-6-yne结构式

1-(tert-butyldi...

~%

(5S,6Z,8E,10E,12R,14Z)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenoate结构式

(5S,6Z,8E,10E,1...

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(2R)-10-((tert-butyldiphenylsilyl)oxy)-1-((tetrahydro-2H-pyran-2-yl)oxy)dec-4-yn-2-ol结构式

(2R)-10-((tert-...

~%

(5S,6Z,8E,10E,12R,14Z)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenoate结构式

(5S,6Z,8E,10E,1...

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(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-ynal结构式

(R)-2,10-bis((t...

~%

(5S,6Z,8E,10E,12R,14Z)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenoate结构式

(5S,6Z,8E,10E,1...

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(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-yn-1-ol结构式

(R)-2,10-bis((t...

~%

(5S,6Z,8E,10E,12R,14Z)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenoate结构式

(5S,6Z,8E,10E,1...

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(5R)-2,2,16,16-tetramethyl-3,3,15,15-tetraphenyl-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-4,14-dioxa-3,15-disilaheptadec-7-yne结构式

(5R)-2,2,16,16-...

~%

(5S,6Z,8E,10E,12R,14Z)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-6,8,10,14-tetraenoate结构式

(5S,6Z,8E,10E,1...

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(5R)-2,2,16,16-tetramethyl-3,3,15,15-tetraphenyl-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-4,14-dioxa-3,15-disilaheptadec-7-yne结构式

(5R)-2,2,16,16-...

~91%

(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-yn-1-ol结构式

(R)-2,10-bis((t...

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1-(tert-butyldiphenylsilyloxy)hept-6-yne结构式

1-(tert-butyldi...

~%

(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-yn-1-ol结构式

(R)-2,10-bis((t...

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(2R)-10-((tert-butyldiphenylsilyl)oxy)-1-((tetrahydro-2H-pyran-2-yl)oxy)dec-4-yn-2-ol结构式

(2R)-10-((tert-...

~%

(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-yn-1-ol结构式

(R)-2,10-bis((t...

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(9R)-methyl 9-hydroxy-10-((tetrahydro-2H-pyran-2-yl)oxy)dec-6-ynoate结构式

(9R)-methyl 9-h...

~%

(5S,8E,10E,12R)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-8,10-dien-6,14-diynedioate结构式

(5S,8E,10E,12R)...

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methyl (R)-9-((tert-butyldiphenylsilyl)oxy)-10-hydroxydec-6-ynoate结构式

methyl (R)-9-((...

~%

(5S,8E,10E,12R)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-8,10-dien-6,14-diynedioate结构式

(5S,8E,10E,12R)...

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(9R)-methyl 9-((tert-butyldiphenylsilyl)oxy)-10-((tetrahydro-2H-pyran-2-yl)oxy)dec-6-ynoate结构式

(9R)-methyl 9-(...

~%

(5S,8E,10E,12R)-dimethyl 5,12-bis((tert-butyldiphenylsilyl)oxy)icosa-8,10-dien-6,14-diynedioate结构式

(5S,8E,10E,12R)...

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1-(tert-butyldiphenylsilyloxy)hept-6-yne结构式

1-(tert-butyldi...

~%

(5S,8E,10Z,12R)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-8,10-dien-6,14-diynoate结构式

(5S,8E,10Z,12R)...

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(2R)-10-((tert-butyldiphenylsilyl)oxy)-1-((tetrahydro-2H-pyran-2-yl)oxy)dec-4-yn-2-ol结构式

(2R)-10-((tert-...

~%

(5S,8E,10Z,12R)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-8,10-dien-6,14-diynoate结构式

(5S,8E,10Z,12R)...

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(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-yn-1-ol结构式

(R)-2,10-bis((t...

~%

(5S,8E,10Z,12R)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-8,10-dien-6,14-diynoate结构式

(5S,8E,10Z,12R)...

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(5R)-2,2,16,16-tetramethyl-3,3,15,15-tetraphenyl-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-4,14-dioxa-3,15-disilaheptadec-7-yne结构式

(5R)-2,2,16,16-...

~%

(5S,8E,10Z,12R)-methyl 5,12,20-tris((tert-butyldiphenylsilyl)oxy)icosa-8,10-dien-6,14-diynoate结构式

(5S,8E,10Z,12R)...

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methyl (R)-9-((tert-butyldiphenylsilyl)oxy)-10-hydroxydec-6-ynoate结构式

methyl (R)-9-((...

~%

(R)-methyl 9-((tert-butyldiphenylsilyl)oxy)-10-oxodec-6-ynoate结构式

(R)-methyl 9-((...

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(9R)-methyl 9-hydroxy-10-((tetrahydro-2H-pyran-2-yl)oxy)dec-6-ynoate结构式

(9R)-methyl 9-h...

~%

(R)-methyl 9-((tert-butyldiphenylsilyl)oxy)-10-oxodec-6-ynoate结构式

(R)-methyl 9-((...

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(9R)-methyl 9-((tert-butyldiphenylsilyl)oxy)-10-((tetrahydro-2H-pyran-2-yl)oxy)dec-6-ynoate结构式

(9R)-methyl 9-(...

~%

(R)-methyl 9-((tert-butyldiphenylsilyl)oxy)-10-oxodec-6-ynoate结构式

(R)-methyl 9-((...

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1-(tert-butyldiphenylsilyloxy)hept-6-yne结构式

1-(tert-butyldi...

~%

(5R)-2,2,16,16-tetramethyl-3,3,15,15-tetraphenyl-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-4,14-dioxa-3,15-disilaheptadec-7-yne结构式

(5R)-2,2,16,16-...

查看详情

(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-yn-1-ol结构式

(R)-2,10-bis((t...

~91%

(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-ynal结构式

(R)-2,10-bis((t...

查看详情

1-(tert-butyldiphenylsilyloxy)hept-6-yne结构式

1-(tert-butyldi...

~%

(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-ynal结构式

(R)-2,10-bis((t...

查看详情

(2R)-10-((tert-butyldiphenylsilyl)oxy)-1-((tetrahydro-2H-pyran-2-yl)oxy)dec-4-yn-2-ol结构式

(2R)-10-((tert-...

~%

(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-ynal结构式

(R)-2,10-bis((t...

查看详情

(5R)-2,2,16,16-tetramethyl-3,3,15,15-tetraphenyl-5-(((tetrahydro-2H-pyran-2-yl)oxy)methyl)-4,14-dioxa-3,15-disilaheptadec-7-yne结构式

(5R)-2,2,16,16-...

~%

(R)-2,10-bis((tert-butyldiphenylsilyl)oxy)dec-4-ynal结构式

(R)-2,10-bis((t...

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(9R)-methyl 9-((tert-butyldiphenylsilyl)oxy)-10-((tetrahydro-2H-pyran-2-yl)oxy)dec-6-ynoate结构式

(9R)-methyl 9-(...

~%

methyl (R)-9-((tert-butyldiphenylsilyl)oxy)-10-hydroxydec-6-ynoate结构式

methyl (R)-9-((...

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(9R)-methyl 9-hydroxy-10-((tetrahydro-2H-pyran-2-yl)oxy)dec-6-ynoate结构式

(9R)-methyl 9-h...

~%

methyl (R)-9-((tert-butyldiphenylsilyl)oxy)-10-hydroxydec-6-ynoate结构式

methyl (R)-9-((...

查看详情