Tetrahedron letters

Rapid synthesis of 11 C-labeled FK506 for positron emission tomography

Y Murakami, A Kuroda, K Osoda, S Nishimura

文献索引：Murakami, Yoshihiro; Kuroda, Akio; Osoda, Kazuhiko; Nishimura, Shintaro Tetrahedron Letters, 2003 , vol. 44, # 4 p. 641 - 644

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被引用次数: 9

摘要

The present study describes a rapid synthesis method for labeled [11C] FK506 for positron emission tomography (PET). A one-pot reaction from [11C] CH3I, involving a Wittig reaction as the key carbon carbon bond formation was developed. The chemical process was accomplished using a designed, fully automated synthetic apparatus, and an injectable solution of [11C] FK506 was obtained in only 34 min from [11C] CH3I. The decay- ...