Synthesis and biochemical evaluation of guanidino-alkyl-ribitol derivatives as nucleoside hydrolase inhibitors

…, G Surpateanu, P Van Der Veken, S De Prol…

文献索引：Goeminne; McNaughton; Bal; Surpateanu; Van Der Veken; De Prol; Versees; Steyaert; Haemers; Augustyns European Journal of Medicinal Chemistry, 2008 ,  vol. 43,  # 2  p. 315 - 326

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被引用次数: 18

摘要

Nucleoside hydrolase (NH) is a key enzyme in the purine salvage pathway. The purine specificity of the IAG-NH from Trypanosoma vivax is at least in part due to cation–π-stacking interactions. Guanidinium ions can be involved in cation–π-stacking interactions, therefore a series of guanidino-alkyl-ribitol derivatives were synthesized in order to examine the binding affinity of these compounds towards the target enzyme. The compounds show moderate to ...