前往化源商城

Synthesis and Anticholinergic Activity of the Four Stereoisomers of 4-(Dimethylamino)-2-phenyl-2-(2-pyridyl) pentanamide

H Oyasu, M Nagano, A Akahane, M Tomoi…

文献索引:Oyasu, Hitoshi; Nagano, Masanobu; Akahane, Atsushi; Tomoi, Masaaki; Tada, Toshiji; Matsuo, Masaaki Journal of Medicinal Chemistry, 1994 ,  vol. 37,  # 9  p. 1378 - 1381

全文:HTML全文

被引用次数: 7

摘要

Anticholinergic agents which act on the muscarinic receptor have been utilized in the clinic, eg, for treating spasm of internal organs. Terodiline and oxybutynin recently exploited a new clinical application of anticholinergics for the treatment of overactive detrusor syndrome associated with bladder muscle instability. The clinical effect of these drugs is mainly ascribed to antimuscarinic although both drugs bear additional pharmacological ...