Tetrahedron Letters

Facile synthesis of 4-substituted pyridines using grignard reagents

K Akiba, Y Iseki, M Wada

文献索引：Akiba, Kin-ya; Iseki, Yuji; Wada, Makoto Tetrahedron Letters, 1982 , vol. 23, # 38 p. 3935 - 3936

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被引用次数: 43

摘要

Abstract Nt-Butyldimethylsilylpyridinium triflate 2 reacted with Grignard reagents at 4- position with almost complete regioselectivity (> 99%) to afford the corresponding 1, 4- dihydropyridine derivatives (3), which are easily oxidized by oxygen to give 4-substituted pyridines (4: 58–70%).