Discovery of 4-(dimethylamino) quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1

K Kanuma, K Omodera, M Nishiguchi…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2565 - 2569

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被引用次数: 25

摘要

... Bioorganic & Medicinal Chemistry Letters. ... In addition, MCH was reported to induce an anxiogenic effect when injected into the medical preoptic area in rats ... binding at the CART-MCH-R1 would provide a meaningful SAR-driving assay for our medicinal chemistry approaches and ...