Development of a Scalable Synthesis of Dipeptidyl Peptidase-4 Inhibitor ABT-279

TS McDermott, L Bhagavatula…

文献索引：Organic Process Research and Development, , vol. 13, # 6 p. 1145 - 1155

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被引用次数: 8

摘要

... Organic Process Research & Development. ... Development of a Scalable Synthesis of Dipeptidyl Peptidase-4 Inhibitor ABT-279. ... The overall yield of the process was 65% on 50-kg scale (Scheme 6), and the material produced was greater than 97% pure by HPLC analysis. ...