Identification of a dual histamine H 1/H 3 receptor ligand based on the H 1 antagonist chlorpheniramine

R Aslanian, M wa Mutahi, NY Shih, JJ Piwinski…

文献索引：Aslanian, Robert; Mutahi, Mwangi Wa; Shih, Neng-Yang; Piwinski, John J.; West, Robert; Williams, Shirley M.; She, Susan; Wu, Ren-Long; Hey, John A. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 12 p. 1959 - 1961

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被引用次数: 34

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Combining the first generation H 1 antihistamine chlorpheniramine (1) with H 3 ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H 1 and H 3 receptors. ... The identification of the dual H 1 /H 3 ligand, 9d, is reported.