A new aspect of view in synthesizing new type β-adrenoceptor blockers with ancillary antioxidant activities

YC Huang, BN Wu, JL Yeh, SJ Chen, JC Liang…

文献索引：Huang, Yeun-Chih; Wu, Bin-Nan; Yeh, Jwu-Lai; Chen, Sheue-Jiun; Liang, Jyh-Chong; Lo, Yi-Ching; Chen, Ing-Jun Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 7 p. 1739 - 1746

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被引用次数: 18

摘要

A series of vanilloid-type β-adrenoceptor blockers derived from antioxidant traditional Chinese herbal medicines were synthesized and tested for their antioxidant and adrenoceptor antagonistic activities. They all possessed significant β-adrenoceptor blocking activities under in vitro experiments and radioligand binding assays. In addition, some compounds were further examined in in vivo tests and produced antagonist effects ...