Synthesis

Synthesis and characterization of model ultimate carcinogens/metabolites derived from lead tetraacetate oxidation of arylnitrones: 2′-Deoxyguanosine adducts

…, KRR Kumar, K Mantelingu, KS Rangappa

文献索引：Mallesha; Kumar; Mantelingu; Rangappa Synthesis, 2001 , # 10 p. 1459 - 1461

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被引用次数: 24

摘要

Abstract The synthesis of model reactive metabolites 4a-c by lead tetraacetate (LTA) oxidation of arylnitrones 3a-c is described. Compounds 4a-c react with deoxyguanosine (dG) to give N-benzoylated C8-adducts 5a-c. Following debenzoylation with the heterogeneous system (sodium carbonate/methanol) leads to the corresponding C8- adducts 6a-c.