Photochemical control of RNA structure by disrupting π-stacking

…, A Schön, E Freire, MM Greenberg

文献索引：Resendiz, Marino J. E.; Schoen, Arne; Freire, Ernesto; Greenberg, Marc M. Journal of the American Chemical Society, 2012 , vol. 134, # 30 p. 12478 - 12481

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被引用次数: 10

摘要

Photolabile nucleotides that disrupt nucleic acid structure are useful mechanistic probes and can be used as tools for regulating biochemical processes. Previous probes can be limited by the need to incorporate multiple modified nucleotides into oligonucleotides and in kinetic studies by the rate-limiting step in the conversion to the native nucleotide. Photolysis of aryl sulfide 1 produces high yields of 5-methyluridine, and product formation is complete in ...