2-Iminohomopiperidinium salts as selective inhibitors of inducible nitric oxide synthase (iNOS)

…, CM Kornmeier, PT Manning, JR Connor…

文献索引：Hansen Jr., Donald W.; Peterson, Karen B.; Trivedi, Mahima; Kramer, Steven W.; Webber, Ronald K.; Tjoeng, Foe S.; Moore, William M.; Jerome, Gina M.; Kornmeier, Christine M.; Manning, Pamela T.; Connor, Jane R.; Misko, Thomas P.; Currie, Mark G.; Pitzele, Barnett S. Journal of Medicinal Chemistry, 1998 , vol. 41, # 9 p. 1361 - 1366

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被引用次数: 46

摘要

An attractive approach to the treatment of inflammatory conditions such as osteo-and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through the selective inhibition of human inducible nitric oxide synthase (hiNOS) since localized excess nitric oxide (NO) release has been implicated in the pathology of these diseases. A series of monosubstituted iminohomopiperidinium salts possessing lipophilic functionality at ring ...