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Synthesis and pharmacological properties of benzisothiazole/benzimidazole derivatives with acidic groups

P Vicini, M Incerti, L Amoretti, V Ballabeni, M Tognolini…

文献索引：Vicini, Paola; Incerti, Matteo; Amoretti, Loredana; Ballabeni, Vigilio; Tognolini, Massimiliano; Barocelli, Elisabetta Farmaco, 2002 , vol. 57, # 5 p. 363 - 367

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被引用次数: 22

摘要

The synthesis and the pharmacological evaluation of benzisothiazole and benzimidazole tetrazolyl-and carboxyl-derivatives 1–6 are described. Structural modification was aimed at investigating the influence of two isosteric substituents (tetrazolyl-and carboxyl-) on the title benzofused heterocycles. The antiphlogistic, antipyretic and analgesic activities have been investigated in in vivo experimental models. Additional investigations have been ...