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Synthesis of 6-(3-aryl-2-propenyl)-2, 3-dihydro-5-hydroxybenzofuran derivatives by cross coupling reactions

RJ Alabaster, IF Cottrell, D Hands, GR Humphrey…

文献索引:Alabaster, Ramon J.; Cottrell, Ian F.; Hands, David; Humphrey, Guy R.; Kennedy, Derek J.; et al. Synthesis, 1989 , # 8 p. 598 - 603

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被引用次数: 9

摘要

The synthesis of 6-(3-aryl-2-propcnyl)-2, 3-dihydro-5-hydroxybenzofuran derivatives by cross coupling between 6-bromo-2, 3-dihydrobenzofurans and cinnamyl halides via organo- metallic compounds has been explored. Palladium catalysed reaction between benzofurylzinc bromides and cinnainyl acetates gave high yields of pure products, and the reaction was developed into an economic process for the large scale preparation of 2, 3- ...