Highly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst

W Tang, Y Sun, L Xu, T Wang, Q Fan…

文献索引：Tang, Weijun; Sun, Yawei; Lijin, Xu; Wang, Tianli; Qinghua Fan; Lam, Kim-Hung; Chan, Albert S.C. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 15 p. 3464 - 3471

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被引用次数: 56

摘要

The combination of the readily available chiral bisphosphine ligand Difluorphos with [Ir (COD) Cl] 2 in THF resulted in a highly efficient catalyst system for asymmetric hydrogenation of quinolines at quite low catalyst loadings (0.05–0.002 mol%), affording the corresponding products with high enantioselectivities (up to 96%), excellent catalytic activities (TOF up to 3510 h− 1) and productivities (TON up to 43000). The same catalyst ...