Synthesis and endectocidal activity of novel 1-(arylsulfonyl)-1-[(trifluoromethyl) sulfonyl] methane derivatives

…, KR Dahnke, CK Smith, PJ McDermott

文献索引：Wickiser, David I.; Wilson, Sharon A.; Snyder, Daniel E.; Dahnke, Karl R.; Smith II, Charles K.; McDermott, Paul J. Journal of Medicinal Chemistry, 1998 , vol. 41, # 7 p. 1092 - 1098

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被引用次数: 5

摘要

We have recently synthesized a series of novel disulfonylmethane compounds that have shown anthelmintic and insecticidal (endectocidal) activity. Several analogues have shown activity against the internal nematode Haemonchus contortus. In sheep studies, these analogues have shown 100% control of this internal parasite at a 10 mg/kg rate. In vitro activity against the biting flies, Stomoxys calcitrans and Haematobia irritans, has been ...