The anti-malarial activity of bivalent imidazolium salts
JZ Vlahakis, S Mitu, G Roman, EP Rodriguez…
文献索引：Vlahakis, Jason Z.; Mitu, Simona; Roman, Gheorghe; Rodriguez, E. Patricia; Crandall, Ian E.; Szarek, Walter A. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 21 p. 6525 - 6542
A series of compounds containing bivalent imidazolium rings and one triazolium analog were synthesized and evaluated for their ability to inhibit the replication of Plasmodium falciparum cultures. The activity and selectivity of the compounds for P. falciparum cultures were found to depend on the presence of electron-deficient rings that were spaced an appropriate distance apart. The activity of the compounds was not critically dependent on ...
