Synthesis of large macrocyclic tetraaza compounds with a methylene backbone: Cyclo [??NH??(CH2) n??] 4,(n= 6, 7, 8, 9 and 10). The formation of 28??, 32??, 36??, 40??and …

T Tomohiro, K Uoto, HY Okuno

文献索引：Tomohiro, Takenori; Uoto, Kouichi; Okuno, Hiroaki (Yohmei) Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 5 p. 1233 - 1239

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被引用次数: 6

摘要

Abstract A series of macrocyclic tetraamines with 28-, 32-, 36-, 40-and 44-membered rings have been efficiently prepared from the corresponding ditosylamide and monobromoalcohol derivatives in 6 steps via a double condensation reaction. Overall yields were: 41, 41, 46, 29, and 33%, respectively, for 1, 8, 15, 22-tetraazacyclooctacontane (11a), 1, 9, 17, 25- tetraazacyclodotriacontane (11b), 1, 10, 19, 28-tetraazacyclohexatriacontane (11c), 1, 11, ...