Triaza-based amphiphilic chelators: Synthetic route, in vitro characterization and in vivo studies of their Ga (III) and Al (III) chelates

…, MIM Prata, CFGC Geraldes, JP André

文献索引：de Sa, Arsenio; Prata, M. Isabel M.; Geraldes, Carlos F.G.C.; Andre, Joao P. Journal of Inorganic Biochemistry, 2010 , vol. 104, # 10 p. 1051 - 1062

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被引用次数: 17

摘要

Radiogallium chelates are important for diagnostic imaging in nuclear medicine (PET (positron emission tomography) and γ-scintigraphy). Micelles are adequate colloidal vehicles for the delivery of therapeutic and diagnostic agents to organs and tissues. In this paper we describe the synthesis and in vitro and in vivo studies of a series of micelles- forming Ga (III) chelates targeted for the liver. The amphiphilic ligands are based on NOTA ...