European journal of medicinal chemistry

Unprecedented synthesis, in vitro and in vivo anti-cancer evaluation of novel triazolonaphthalimide derivatives

S Li, W Zhong, Z Li, X Meng

文献索引：Li, Shasha; Zhong, Wenhe; Li, Zhongjun; Meng, Xiangbao European Journal of Medicinal Chemistry, 2012 , vol. 47, # 1 p. 546 - 552

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被引用次数: 5

摘要

An efficient synthesis method for fusing triazole ring onto the naphthalimide core was described. The anti-cancer activities of the generated triazolonaphthalimide derivatives were evaluated with five cancer cell lines. The compounds generally displayed higher potency than amonafide. 4d, 4e carrying two amino side chains showed the strongest cytotoxicities. N-oxide 5, a prodrug of 4a, was designed and synthesized. The agent was expected to be ...