Biological evaluation of bishydroxymethyl-substituted cage dimeric 1, 4-dihydropyridines as a novel class of p-glycoprotein modulating agents in cancer cells
M Richter, J Molnár, A Hilgeroth
文献索引：Richter, Martin; Molnar, Josef; Hilgeroth, Andreas Journal of Medicinal Chemistry, 2006 , vol. 49, # 9 p. 2838 - 2840
A series of N-substituted cage dimeric 1, 4-dihydropyridines 3a-e was evaluated as inhibitors of membrane efflux pump P-glycoprotein (P-gp) in multidrug resistant (mdr) cancer cells. Structure-activity relationships (SAR) and cytotoxic properties are discussed. Effective concentrations for overcoming mdr have been demonstrated in competition studies with the P-gp substrate epirubicin.
