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Asymmetric Synthesis of 2 H-Azirine Carboxylic Esters by an Alkaloid-Mediated Neber Reaction

…, GJA Ariaans, B Zwanenburg

文献索引:Verstappen, Marielle M. H.; Ariaans, Gerry J. A.; Zwanenburg, Binne Journal of the American Chemical Society, 1996 , vol. 118, # 35 p. 8491 - 8492

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被引用次数: 82

摘要

The highly strained and reactive 2H-azirines have been extensively studied for various synthetic purposes, such as ring expansion reactions, 1, 2 cycloaddition reactions, 2, 3 and preparation of functionalized amines3 and substituted aziridines. 1-3 The applicability of these small-ring heterocycles is strongly determined by the nature of the substituents. 2, 3 2H-Azirine 2-carboxylic acids and esters are of particular interest as they form an entrée to ...