MAO inhibition by arylisopropylamines: the effect of oxygen substituents at the β-position

…, MC Rezende, S Sepúlveda-Boza, BK Cassels…

文献索引：Osorio-Olivares, Mauricio; Rezende, Marcos Caroli; Sepulveda-Boza, Silvia; Cassels, Bruce K.; Fierro, Angelica Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 15 p. 4055 - 4066

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被引用次数: 15

摘要

Twenty-nine arylisopropylamines, substituted at the β-position of their side chain by an oxo, hydroxy, or methoxy group, were evaluated in vitro as MAO-A and MAO-B inhibitors. The oxo derivatives (cathinones') were in general less active as MAO-A inhibitors than the corresponding arylisopropylamines, but exhibited an interesting MAO-B inhibiting activity, which was absent in the hydroxy, methoxy, and β-unsubstituted analogues. These results ...