前往化源商城

Organic letters

… -carbon bond-forming enantioselective synthesis of chiral organosilicon compounds by Rhodium/chiral diene-catalyzed asymmetric 1, 4-addition reaction

R Shintani, K Okamoto, T Hayashi

文献索引:Shintani, Ryo; Okamoto, Kazuhiro; Otomaru, Yusuke; Ueyama, Kazuhito; Hayashi, Tamio Journal of the American Chemical Society, 2005 , vol. 127, # 1 p. 54 - 55

全文:HTML全文

被引用次数: 89

摘要

A new synthetic method for chiral organosilicon compounds through a rhodium-catalyzed asymmetric 1, 4-addition of arylboronic acids to β-silyl α, β-unsaturated carbonyl compounds has been developed. By employing (R, R)-Bn-bod* as a ligand, a range of arylboronic acids can be coupled with these substrates in very high enantiomeric excess. The resulting β-silyl 1, 4-adducts can be converted to β-hydroxy carbonyl compounds or allylsilanes while ...

 相关合成线路

~99%

~%

~99%

~66%

~%

~%

~%

~%

~%

~%

~%

~%

~68%

~%

~%

~76%

~%

~%

~%

~%

~%

~%

~50%

~99%

~%

~%

~91%

~%

~59%

~%

~80%

~%

~%

~%

~%

~%