A method has been devised by which linoleic acid isolated from natural sources may be used as a starting material for the preparation of the substance labeled with isotopic carbon in the carboxyl group. In essence, the original carboxyl group is replaced by a bromine atom uia the silver salt degradation of Borodin and the process reversed via the Grignard reaction, the sensitive and synthetically-imposing cis, cis-1, 4-diene moiety being protected in steps ...
