Tetrahedron letters

Pea-seedling diamine oxidase: applications in synthesis and evidence relating to its mechanism of action

JE Cragg, RB Herbert, MM Kgaphola

文献索引：Cragg, John E.; Herbert, Richard B.; Kgaphola, Mashupye M. Tetrahedron Letters, 1990 , vol. 31, # 47 p. 6907 - 6910

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被引用次数: 9

摘要

Abstract Diamines (6)–(8) and (11) act as acceptable substrates for diamine oxidase (DAO) and the novel phenacyl derivatives (2) are obtained in satisfactory preparative yield; no enantioselectivity is observed with (11) as an enzyme substrate. Remarkably, the triamines (9) and (13) are not oxidized and, moreover,(9) acts as a notable inhibitor for the DAO catalysed oxidation of (4) and (5). Kinetic evidence relevant to the mechanism of DAO ...