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Organic Disulfides and Related Substances. IX. 1a Symmetrical Aminothiolsulfonates as Antiradiation Drugs1b

L Field, A Ferretti, RR Crenshaw…

文献索引:Field,L. et al. J. Med. Chem., 1964 , vol. 7, p. 39 - 44

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被引用次数: 15

摘要

Various symmetrical aminothiolsulfonates were investigated with respect to influences of structure both on protective activity against ionizing radiation and on preparation and properties. In comparison with the thiolsulfonate obtained by oxidizing cysteamine hydrochloride, a chain of five carbon atoms instead of two or acylation of the amine by guanyl or acetyl likewise resulted in quite satisfactory preparation; protective activity ...