5-Carboxy-5-methyl-1-pyrroline N-oxide: a spin trap for the hydroxyl radical

…, AD Parasca, ED Barth, C Mailer, HJ Halpern…

文献索引：Tsai; Elas; Parasca; Barth; Mailer; Halpern; Rosen Journal of the Chemical Society, Perkin Transactions 2, 2001 , # 6 p. 875 - 880

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被引用次数: 20

摘要

The in vivo in situ detection of hydroxyl radical (HO) in real time has been one of the great challenges of free radicals in biology. While we have been able to identify this free radical as a secondary biomarker of HO, the discovery that 5-carboxy-5-methyl-1-pyrroline N-oxide 2 can specifically spin trap HO at the expense of superoxide (O 2−) opens new avenues of research. In particular, nitrone 2 will allow us to detect HO from low doses of radiation in ...