A water soluble dimeric steroid with catalytic properties. Rate enhancements from hydrophobic binding

…, J Cossar, BA Dawson

文献索引：Guthrie, J. Peter; Cossar, John; Dawson, Brian A. Canadian Journal of Chemistry, 1986 , vol. 64, p. 2456 - 2469

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被引用次数: 44

摘要

Dimeric steroids can be formed by reductive amination of terephthalaldehyde with 3-amino steroids using cyanoborohydride. An amino group in the 11β-position can be blocked using a formyl group, and this can be removed by acid hydrolysis after dimerization. Trifluoroacetyl is not a suitable blocking group; although it can be removed by acid hydrolysis from monomeric steroids, it was only removed from the dimer under forcing conditions which ...