Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone

J Song, V Malathong, CR Bertozzi

文献索引：Song, Jie; Malathong, Viengkham; Bertozzi, Carolyn R. Journal of the American Chemical Society, 2005 , vol. 127, # 10 p. 3366 - 3372

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被引用次数: 190

摘要

The controlled integration of organic and inorganic components confers natural bone with superior mechanical properties. Bone biogenesis is thought to occur by templated mineralization of hard apatite crystals by an elastic protein scaffold, a process we sought to emulate with synthetic biomimetic hydrogel polymers. Cross-linked polymethacrylamide and polymethacrylate hydrogels were functionalized with mineral-binding ligands and used to ...