New bivalent PKC ligands linked by a carbon spacer: enhancement in binding affinity

…, LV Pearce, PM Blumberg, AP Kozikowski

文献索引：Sridhar, Jayalakshmi; Wei, Zhi-Liang; Nowak, Ireneusz; Lewin, Nancy E.; Ayres, Jolene A.; Pearce, Larry V.; Blumberg, Peter M.; Kozikowski, Alan P. Journal of Medicinal Chemistry, 2003 , vol. 46, # 19 p. 4196 - 4204

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被引用次数: 39

摘要

Protein kinase C (PKC) is known to play an important role in many signal transduction pathways involved in hormone release, mitogenesis, and tumor promotion. In continuation of our efforts to find highly potent activators of PKC for possible use as Alzheimer's disease therapeutics, we designed and synthesized molecules containing two binding moieties (amides of benzolactams or esters of naphthylpyrrolidones) connected by a flexible ...