Nucleosides, Nucleotides and Nucleic Acids

Synthesis and anti-hepatitis C virus activity of 2′(β)-hydroxyethyl and 4′(α)-hydroxymethyl carbodine analogues

LJ Liu, JH Hong

文献索引：Liu, Lian Jin; Hong, Joon Hee Nucleosides, Nucleotides and Nucleic Acids, 2009 , vol. 28, # 11-12 p. 1007 - 1015

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被引用次数: 4

摘要

2′(β)-Hydroxyethylated adenosine is a potent and selective inhibitor of hepatitis C virus (HCV) replication targeting the RNA-dependent RNA polymerase of HCV, NS5B. The synthesis and anti-HCV evaluation of carbodine analogues are described. The cyclopentene intermediate 10 was successfully made via sequential Johnson-Claisen orthoester rearrangement and ring-closing metathesis. Coupling of bases via a Pd (0) ...