Synthesis and antitubercular evaluation of novel substituted aryl and thiophenyl tethered dihydro-6H-quinolin-5-ones

S Kantevari, SR Patpi, B Sridhar, P Yogeeswari…

文献索引：Kantevari, Srinivas; Patpi, Santhosh Reddy; Sridhar, Balasubramanian; Yogeeswari, Perumal; Sriram, Dharmarajan Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 4 p. 1214 - 1217

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被引用次数: 20

摘要

A series of novel aryl and thiophenyl tethered dihydro-6H-quinolin-5-ones have been synthesized in very good yields through CeCl3· 7H2O–NaI catalyzed one-pot condensation of β-enaminones derived from the respective methyl ketones; 1, 3-cyclohexanedione & 5, 5- dimethyl-1, 3-cyclohexanedione and ammonium acetate refluxing in 2-propanol. Dihydro-6H- quinolin-5-ones 3a–f was further derivatized to the respective hydroxymethyl analogs ...